It is definintely possible, however you wont have discrete control of the sub from the OEM head unit as you would get with an aftermarket head unit, and you will need either an external line level converter, or buy an amp with speaker level inputs. That said, you can by amps these days that have remote level control to allow you to change the sub volume independently of the main system volume... such as these:
One other issue you may come across is that typically OEM head units are not the best at low, sub frequencies and you will get much better sound quality from an aftermarket system.
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